How to Treat Small Cell Lung Cancer using Treatment Algorithm with Dr. Eric Singhi

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In this episode of the Oncology Brothers podcast, we had the pleasure of discussing small cell lung cancer with Dr. Eric Singhi, a thoracic medical oncologist from MD Anderson Cancer Center.

Key Points:

•⁠ ⁠The Adriatic study’s impact on improving overall survival with Durvalumab in limited stage disease.
•⁠ ⁠Treatment options for extensive stage disease, including second-line therapies like Lurbinectedin and the recent approval of Tarlatamab.
•⁠ ⁠The significance of individualized treatment decisions and ongoing research in small cell lung cancer management.

The episode delved into various aspects of small cell lung cancer, starting with the management of limited stage disease. Dr. Singhi highlighted the importance of assessing surgical candidacy for patients with small primary tumors and no nodal involvement, followed by postoperative pathology review and adjuvant platinum-based therapy.

The conversation then shifted to the role of prophylactic cranial irradiation (PCI) in limited stage disease, with Dr. Singhi emphasizing the need for shared decision-making and multidisciplinary discussions with patients. The discussion also touched on the recent practice-changing data from the Adriatic study, which showed improved survival with Durvalumab in limited stage small cell lung cancer.

Moving on to extensive stage disease, the standard of care was discussed, including the use of platinum-based chemotherapy with Atezolizumab or Durvalumab. Second-line treatment options such as Lurbinectedin and the recent approval of Tarlatamab were also discussed. Dr. Singhi provided insights into the administration and monitoring of Tarlatamab, highlighting the importance of patient education and close monitoring for cytokine release syndrome. The episode concluded with a discussion on the management of patients with small cell lung cancer and driver mutations, emphasizing the need for individualized treatment approaches. Dr. Singhi also highlighted the importance of patient advocacy groups, such as the Small Cell Smashers, in providing support for patients with small cell lung cancer.

Overall, the episode provided a comprehensive overview of the current treatment landscape for small cell lung cancer, showcasing the advancements and challenges in managing this devastating disease.

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Dr. Rahul

Dr. Rahul is a Chief of Medical Oncology, making up one-half of the ‘Oncology Brothers.’ He is a valued member of the Guthrie Corning Cancer Center, contributing his extensive knowledge of technology