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Algorithms Journal of Hematology

How to Treat Chronic Lymphocytic Leukemia (CLL) with Dr. Jeff Sharman

How to Treat Chronic Lymphocytic Leukemia (CLL)

In discussion with Dr. Jeff Sharman, about how to treat CLL. Chronic lymphocytic leukemia course has changed since we have started using BTK inhibitors. Dr. Sharman, director of hematology research at US Oncology Network and Director of Research at Willamette Valley Cancer Institute, was the first to ever give this medication here in the US. We discuss important nuances of CLL management with him, when to proceed with observation vs. treatment, when treating what BTKi to utilize, important side effects one has to keep in mind, and much more.

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Journal Club

Polatuzumab FDA Approval in DLBCL (POLARIX) & SWOG S1826 Nivo vs. BV in Hodgkin’s Lymphoma

Discussing two important lymphoma studies, POLARIX which led to the approval of Polatuzumab in DLBCL patients and SWOG S1826 comparing Nivolumab vs. BV with AVD in Hodgkin’s Lymphoma patients with Dr. Jonathan Friedberg. In discussion with the lead author, Dr. Jonathan Friedberg – Director of Wilmot Cancer Institute, Professor of Medicine at University of Rochester Medical Center, and Editor-in-Chief at Journal of Clinical Oncology (JCO).

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Algorithms Journal of Lung Cancer

Story of Hope by a Determined Lung Cancer Survivor – Jill Feldman

Discussing the story of hope and determination from the lung cancer survivor herself, Jill Feldman. Jill, talks about her lung cancer journey from limited stage to advanced stage with metastases, and how novel therapies have given her another chance of reliving her life, dreams and spending quality time with friends and family. Jill, has been an active patient advocate in the cancer space, and co-founder of EGFR Positive Lung Cancer Resisters Advocacy Group.

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Journal Club

EV-103 Study by Dr. Jonathan Rosenberg led to the FDA Approval of Enfortumab + Pembrolizumab

Discussing the EV-103 Cohort K study, which resulted in the FDA approval of Enfortumab Vedotin + Pembrolizumab FDA Approval in the Cisplatin ineligible advanced urothelial carcinoma patients. In discussion with the lead author, Dr. Jonathan Rosenberg – Chief of Genitourinary Oncology Service at Memorial Sloan Kettering Cancer Center.

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Algorithms Journal of Hematology

How to Treat MGUS and Smoldering Myeloma with Dr. S. Vincent Rajkumar

Discussing how to treat MGUS (Monoclonal gammopathy of undetermined significance) and Smoldering Myeloma using an algorithm with Dr. S. Vincent Rajkumar. We covered MGUS and smoldering myeloma in great detail, following with how these patients should be monitored and if any of these patients should be treated. Dr. S. Vincent Rajkumar is a world-renowned physician who specializes in plasma cell disorders – Professor of Medicine at the Mayo Clinic Comprehensive Cancer Center.

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Algorithms Journal of Hematology

How to Treat Multiple Myeloma with Dr. Jens Hillengass

Discussing how to treat multiple myeloma using an algorithm with Dr. Jens Hillengass. We cover the first line, following that recurrence and refractory myeloma management in great detail. Dr. Jens Hillengass is the Chief of Myeloma, Professor of Oncology and Internal Medicine at the Roswell Park Comprehensive Cancer Center – University at Buffalo.

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2023 ASCO

Critical Updates in Kidney, Prostate, and Bladder Cancer from ASCO 2023 with Dr. Toni Choueiri

Discussing GU (Genitourinary) Cancer ASCO 2023 Highlights, focusing on practice changing studies with Dr. Toni Choueiri, Director, Lank Center for Genitourinary Oncology and Professor of Medicine at Harvard Medicine School – Dana-Farber Cancer Institute.

Covering four important studies:

– TALAPRO-2: Ph3 study of talazoparib + enzalutamide vs placebo + enzalutamide as first-line (1L) treatment for mCRPC with homologous recombination repair (HRR) gene alterations

– CLEAR: 4-year follow-up of lenvatinib plus pembrolizumab vs sunitinib in pts with advanced renal cell carcinoma

– CONTACT-03: efficacy and safety of atezolizumab plus cabozantinib vs cabozantinib alone after progression with prior checkpoint inhibitor in metastatic renal cell carcinoma

– THOR: Erdafitinib vs chemo in pts with advanced or metastatic urothelial cancer with select FGFR alteration

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Journal Club

EMERALD Ph III Study in discussion w/ Dr. Virginia Kaklamani (now FDA Approved)

Discussing the EMERALD Phase III study which resulted in the FDA approval of the first oral selective estrogen receptor degrader (SERD) after demonstrating statistically significant and clinically meaningful benefit in postmenopausal women and men, with ER+, HER2- metastatic breast cancer patients, post progression in first line with endocrine therapy and CDK4/6i. In discussion with Dr. Virginia Kaklamani – Professor of Medicine – Leader of Breast Oncology Program UT Health San Antonio MD Anderson Cancer Center.

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Dr. Rahul

Dr. Rahul is a Chief of Medical Oncology, making up one-half of the ‘Oncology Brothers.’ He is a valued member of the Guthrie Corning Cancer Center, contributing his extensive knowledge of technology