How to treat Myelofibrosis – Discussion with Dr. Naveen Pemmaraju

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In this episode of the Oncology Brothers podcast, we discussed the complexities of myelofibrosis, a challenging blood cancer. Dr. Naveen Pemmaraju from MD Anderson Cancer Center provided valuable insights into the diagnosis, prognosis, and management of myelofibrosis. Key points discussed included the importance of bone marrow biopsy, molecular analysis, and risk stratification using various scoring systems.

The discussion highlighted that while allogeneic stem cell transplant remains the only potential cure, JAK inhibitors such as ruxolitinib, fadratinib, pacritinib, and momelotinib have shown efficacy in controlling symptoms and disease progression. It was emphasized that JAK inhibitors can benefit patients regardless of JAK2 mutation status.

Unique side effects of different JAK inhibitors were also addressed, along with strategies to manage them. Supportive care options like erythropoietin-stimulating agents and luspatercept for anemia were discussed, as well as the importance of considering individual patient factors in treatment decisions.

Overall, the episode provided a comprehensive overview of myelofibrosis treatment options and highlighted the need for a personalized approach to patient care in this complex disease.

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Dr. Rahul

Dr. Rahul is a Chief of Medical Oncology, making up one-half of the ‘Oncology Brothers.’ He is a valued member of the Guthrie Corning Cancer Center, contributing his extensive knowledge of technology