Discussion on Evolving CLL Treatment Strategies with Dr. Nitin Jain

As the host of this podcast episode focusing on hematologic malignancies, we had the privilege of discussing CLL treatment options with Dr. Nitin Jain from MD Anderson Cancer Center. Dr. Jain provided valuable insights on determining when a patient with CLL needs treatment, the minimal workup required, and the decision-making process between time-limited venetoclax and long-term BTK inhibitors. We delved into the importance of cytogenetic markers, such as deletion 17P and TP53 mutation, in guiding treatment choices. Dr. Jain highlighted the significance of IGHV mutation analysis and the evolving landscape of CLL treatment, including the use of second-generation BTK inhibitors like Acalabrutinib and Zanabrutinib.

We also explored the considerations for using venetoclax with or without Obinutuzumab, as well as the challenges and benefits associated with each approach. Dr. Jain shared his expertise on managing side effects, logistical challenges, and patient preferences when selecting treatment options. Additionally, we discussed the emerging therapies for patients who have failed first and second-line treatments, such as Partobrutinib and CAR T-cell therapy.

Overall, this episode provided a comprehensive overview of the current treatment landscape for CLL, emphasizing the importance of individualized patient care and the exciting advancements in hematologic malignancy treatment. Stay tuned for more discussions on myeloma and myelofibrosis in future episodes. Thank you for joining us on this informative journey through the world of oncology.

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Dr. Rahul

Dr. Rahul is a Chief of Medical Oncology, making up one-half of the ‘Oncology Brothers.’ He is a valued member of the Guthrie Corning Cancer Center, contributing his extensive knowledge of technology